KITSW Main page
Dept. of Physical Sciences
KITS Warangal
 
Faculty Profile
Address/Contact
Office : Room No. 219, Block IV, Dept. of Physical Sciences
Phone: 0870-2564888
Mobile: 6305936592
 
Education
B.Sc., Kakatiya University, Warangal. (2007).
M.Sc., (Organic Chemistry), Osmania University, Hyderabad. (2009).
Ph.D., (Bio-organic Chemistry) CSIR-Indian Institute of Chemical Technology, Hyderabad, India (2016)
Thesis Title: Design, Synthesis and Bioactivity Evaluation of Novel Cationic Amphiphiles for use in Targeted Chemotherapy and Cancer Immunotherapy.
Dr. Gopi Krishna Moku
ASSISTANT PROFESSOR
PhysicalSciences Department
 
ACADEMIC AFFILIATION
Details

FromTo

Name of the Organization
Assistant Professor

12-07-2019

Till Date

 

Kakatiya Institute of Technology & Science(KITS)
Post Doctoral Research Associate

07-71-2016

31-01-2019

 

University of Minnesota, Twin cities, Minnesota, USA

 

 

 

 

 

 

RESEARCH INTERESTS
  • Organic Synthesis
  • Green Synthesis
  • Materials Science
  • Medicinal Chemistry
PUBLICATIONS
Publications  in Refereed Journals

S. No

Details                                                                                                                                               
1
Sugata Barui, Soumen Saha, Venu Yakati, Gopikrishna Moku, Arabinda Chaudhuri. Tumor-selective chemotherapy combined with in vivo dendritic cell targeted genetic immunization results in regulatory Tcell driven eradication of established mouse melanoma. Communicated to Biomaterials (Under review; Impact Factor 10.31).
2
Venu Yakati, Swathi Vangala, Vijay Sagar Madamshetty, Rajkumar Banerjee, Gopikrishna Moku* A novel approach for combating colon cancer. Communicated to Journal of Drug Delivey Science and Technology (Under review; Impact Factor 2.73), *Corresponding author.
3
Gopikrishna Moku,* Swathi Vangala, Venu Yakati, Chaitanya Chakravarthi Gali, Soumen Saha, Vijay Sagar Madamsetty, Amber Vyas. Novel Suberoylanilide hydroxamic acid analogs inhibit angiogenesis and induce apoptosis in breast cancer cells. Accepted in Anti-cancer Agents in Medicinal Chemistry (Impact Factor 2.01), *Corresponding author.
4
Gopikrishna Moku,* Swathi Vangala, Suresh Kumar Gulla, Venu Yakati. In vivo targeting of DNA vaccines to dendritic cells via the mannose receptor induces long-lasting immunity against melanoma. ChemBioChem 2021, 22, 523-531 (Impact Factor 2.57) *Corresponding author.
5
Swathi Vangala, Gopikrishna Moku* Polymeric nanoparticles for cancer gene therapy. Biomedical Journal of Scientific and Technical Research 2021, 34, 26812-26815 (Impact Factor 1.54) *Corresponding author.
6
Swathi Vangala, Gopikrishna Moku* Enhancement of therapeutic efficacy of mesenchymal stem cells by genetic modification. Asia-Pacific Journal of Clinical Oncology 2021, 2, 1-6 *Corresponding author
7
Swathi Vangala, Gopikrishna Moku* Fabrication and bioactivity evaluation of curcumin and paclitaxel loaded lipid nanoparticles of pH-sensitive histidinylated cationic amphiphile. Asia-Pacific Journal of Clinical Oncology 2021, 2, 7-16 *Corresponding author.
8
Soumen Saha, Venu Yakati, Gajji Shankar, Madan Mohan Chandra Sekhar Jaggarapu, Gopikrishna Moku, Kuncha Madhusudana, Rajkumar Banerjee, Sistla Ramkrishna, Ragampeta Srinivas and Arabinda Chaudhuri. Amphetamine decorated cationic lipid nanoparticles cross the blood–brain barrier: therapeutic promise for combating glioblastoma. Journal of Materials Chemistry B 2020, 8, 4318-4330 (Impact Factor 5.34).
9
Gopikrishna Moku, Buddhadev Layek, Lana Trautman, Samuel Putnam, Jayanth Panyam and Swayam Prabha. Improving payload capacity and anti-tumor efficacy of mesenchymal stem cells using TAT peptide functionalized polymeric nanoparticles. Cancers 2019, 11, 491. (Impact Factor 6.07)
10
Suresh Kumar Gulla, Bonda Rama Rao, Gopikrishna Moku, Sudhakar Jinka, Narendra Varma immu, Sara Khalid, Chitta Ranjan Patra and Arabinda Chaudhuri. In vivo targeting of DNA vaccines to dendritic cells using functionalized gold nanoparticles. BiomaterIal Science 2019, 7, 773-788. (Impact Factor 5.25)
11
Zhixin Lei, Qianying Liu, Qianqian Zhu, Bing Yang, Haseeb Khaliq, Ao Sun, Yi Qi, Gopikrishna Moku, Yafan Su, Jiawei Wang, Jiyue Cao and Qigai He. Comparative pharmacokinetics and preliminary pharmacodynamics evaluation of piscidin 1 against PRV and PEDV in rats. Frontiers in Chemistry 2018, 6, 244. (Impact Factor 3.78)
12
Zhixin Lei, Qianying Liu, Yi Qi, Bing Yang, Haseeb Khaliq, Jincheng Xiong, Gopikrishna Moku, Saeed Ahmed, Kun Li, Hui Zhang, Wenqiu Zhang, Jiyue Cao and Qigai He. Optimal regimens and cutoff evaluation of tildipirosin against Pasteurella multocida. Frontiers in Pharmacology 2018, 9, 765. (Impact Factor 4.40)
13
Gopikrishna Moku, Suresh Kumar Gulla, NarendraVarma Nimmu, Sara Khalid and Arabinda Chaudhuri. Delivering anti
cancer drugs with endosomal pH-sensitive anti-cancer liposomes. Biomaterials Science 2016, 4, 627-638. (Impact
Factor 5.25)
14
Arup Garu, Gopikrishna Moku, Suresh Kumar Gulla, and Arabinda Chaudhuri. Genetic immunization with in vivo
dendritic cell targeting liposomal DNA vaccine carrier induces long-lasting anti-tumor immune response. Molecular
Therapy 2016, 24, 385-397. (Impact Factor 8.40) (≠Equally contributing Co-first Authors).
15
Arup Garu, Gopikrishna Moku, Suresh Kumar Gulla, Dipankar Pramanik, Bharat K Majeti, Priya P Karmali, Haseena
Shaik, Bojja Sreedhar and Arabinda Chaudhuri. Examples of tumor growth inhibition properties of liposomal
formulations of pH-sensitive histidinylated cationic amphiphiles. ACS Biomaterials Science & Engineering 2015, 1,
646-655. (Impact Factor 4.51) (≠Equally contributing Co-first Authors)
16
Srinivas Ramishetti, Arup Garu, Gopikrishna Moku, Sachin B Agwane and Arabinda Chaudhuri. A Long-lasting dendritic
cell DNA vaccination system using lysinylated amphiphiles with mannose-mimicking head-groups. Biomaterials 2012
Publications in Refereed Conference Proceedings

S.No

Details
1
Gopikrishna Moku. Therapeutic efficacy of mesenchymal stem cells engineered with TAT peptide functionalized nanoparticle in an orthotopic lung tumor model. Online webinar on Carbon Materials and Nanotechnology (CMAN-2021), January 07, 2021.
2
Gopikrishna Moku. In vivo targeting of liposomally complexed DNA vaccines to dendritic cells induce long lasting protection against melanoma tumor. Nanomedicine 2020; October 08, 2020; London, UK, ISSN: 2347-8810
3
Swayam Prabha, Gopikrishna Moku, Buddhadev Layek, Jayanth Panyam. Mesenchymal stem cells engineered with TAT peptide functionalized nanoparticles improve therapeutic efficacy of paclitaxel in an orthotopic lung tumor model. Cancer Res. 2019, 79 (13 Suppl): Abstract no. 3623. American Association for Cancer Research (AACR) Annual Meeting 2019; Atlanta, GA, USA.
   
PROFESSIONAL AFFILIATION

S.No

Details
1
Member of American Association for Cancer Research(AACR)
COURSES TAUGHT

Undergraduate Level

Courses Taught

Currently Teaching

Course

Semester, Year, Branch

Course

Semester, Year, Branch

Engineering Chemistry (Theory & Practicals)

B.Tech. 1st Year, EEE/CSN

Engineering Chemistry (Theory & Practicals)

B.Tech 1st Year, IT

Environmental Studies
B.Tech. 1st Year, CE/CSE/ECE
Environmental Studies
B.Tech 1st Year, ME
       

Postgraduate Level

   

 

 

   

 

 

SPONSORED PROJECTS

S. No.

Title of Lecture/ Academic Session
Title of Conference/ Seminar etc
Organized by
1
Mesenchymal stem cell mediated drug delivery in cancer therapy
National webinar on ‘Chemistry Research’
TSWRDC (W), Bhupalapally, Telangana, India
2
Therapeutic efficacy of mesenchymal stem cells engineered with TAT peptide functionalized nanoparticle in an orthotopic lung tumor model
Online webinar on Carbon Materials and Nanotechnology (CMAN-2021) January 07, 2021.
STEMIO, Singapore
3
In vivo Targeting of Liposomally complexed DNA Vaccines to Dendritic Cells induce Long Lasting Protection against Melanoma Tumor
4th webinar on Nanotechnology and Nanomedicine, November 12, 2020.
London, UK
       

 

PAPERS PRESENTED IN CONFERENCES/SEMINARS/ WORKSHOPS/SYMPOSIA

S.No

Details

1
Gopikrishna Moku. In vivo Targeting of DNA Vaccines to Dendritic Cells induce anti-tumor immune response against melanoma tumor. “Cancer Science and Therapeutics-2020” organized by The Research Gate Conferences, 1910 Pacific Ave. Suite 5080, Dallas, Texas, USA, October 2020.
2
Gopikrishna Moku. In vivo Targeting of Liposomally complexed DNA Vaccines to Dendritic Cells induce Long Lasting Protection against Melanoma Tumor. “5 th annual Cell and Gene Therapy Symposium” organized by Centre for Stem Cell Research, Christian Medical College Campus, Bagayam, Vellore, September 2020.
3
Moku GK. et al. Eradication of Established Hepatocellular Carcinoma by Targeted Chemotherapy and In vivo dendritic cell targeted DNA vaacination “4 th annual Cell and Gene Therapy Symposium” organized by Centre for Stem Cell Research, Christian Medical College Campus, Bagayam, Vellore, September 2019.
4
Moku GK. et al. Cell-Penetrating Peptide TAT increases cellular uptake of PLGA nanoparticles in Mesenchymal stem cells at “Industrial Partnership for Research in Interfacial and Materials Engineering (IPRIME) annual meeting 2017, University of Minnesota, Minneapolis, USA
5
Moku GK. et al. Dramatically Long Lasting Protection against Melanoma Tumor through Liposomal Targeting of DNA Vaccines to Dendritic Cells at “International Knowledge Millennium Conference” (IKMC), November 2014, HICC, Hyderabad, India.
6
Moku GK. et al. Evidence for Significant Tumor Growth Inhibition Properties of Endosomal pH- Sensitive Cationic Liposomes: A Serendipitous Discovery at “International Conference on Chemical Biology” (ICCB) February 2014, CSIR-IICT, Hyderabad, India.
   


AWARDS

S. No.

Details

1
National Institute of Health (NIH), USA-Post-doctoral Fellowship
2
Awarded Senior Research Fellowship (SRF) by Council of Scientific and Industrial Research, New Delhi, India (2012-2015).
3
Awarded Junior Research Fellowship (JRF) by Council of Scientific and Industrial Research, New Delhi, India (2010- 2012).
4
Qualified NET (National Eligibility Test) for Junior Research Fellowship conducted by CSIR-UGC, New Delhi (2008 December)

PATENTS

S. No.

Details

1
U.S. Patent 9,840,530B2. “Mannose-receptor selective lysinylated cationic amphiphiles and a process for preparation thereof” December 12, 2017.
2
U.S. Patent 2015/0315154 A1. “Histidinylated cationic amphiphiles, process for preparation therof and their liposomal formulation” November 5, 2015
3
Gopikrishna Moku, Suresh Kumar Gulla and Arabinda Chaudhuri. A method for complete regression of hepatocellular carcinoma by targeted chemotherapy in combination with in vivo dendritic cell targeted genetic immunization. (Patent filed, patent application no. awaited).
   
 
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